Background: Reconstruction of teeth using partial or complete dentures is the only treatment for most edentulous patients. The duration of edentulism and the use of complete dentures can affect the patient’, s quality of life. Therefore, this study aimed to evaluate the quality of life associated with oral health in patients referring to the Prosthodontics Department, School of Dentistry, Sari, Iran. Methods: In total, 235 patients treated in the Prosthodontics Department, School of Dentistry, Sari, Iran were selected and studied in this descriptive-analytical cross-sectional study. The required information was collected using the Oral Health Impact Profile-14 questionnaire (OHIP-14). Data were analyzed through SPSS22 and using descriptive and analytical tests, such as Mann-Whitney, t test, one-way analysis of variance, and multivariate regression. Results: In total, 103 men (43. 8%) and 132 women (56. 2%) with mean age of 58 ±,10. 3 years participated in this study. The duration of denture use was between 3 and 108 months. The mean score of patients’,quality of life had a statistically significant relationship with the type of treated jaw, the type of removable prosthesis, and the duration of prosthesis use (P < 0. 05). However, no statistically significant relationship was observed between the mean score of quality of life with age and gender (P > 0. 05). Conclusion: Based on the obtained results, the quality of life was higher among those who used dentures for a longer period of time and also in patients with complete dentures. However, the quality of life was lower in people who used mandibular dentures, compared to other groups.